Augmentin 1000 is a combined antibiotic containing amoxicillin and clavulanic acid, with a broad spectrum of bactericidal action, resistant to beta-lactamase.
Amoxicillin is a broad spectrum semi-synthetic antibiotic that is active against many Gram-positive and Gram-negative microorganisms. Amoxicillin is destroyed by beta-lactamase and does not affect the microorganisms that produce the enzyme. The mechanism of its action consists in inhibiting the biosynthesis-mucopeptides of the cell wall.
Clavulanic acid is a beta-lactamate structurally related to penicillins, which has the ability to inactivate a wide range of beta-lactamases. Beta-lactamases are produced by many Gram-positive game negative bacteria. The action of beta-lactamases can lead to the destruction of some antibacterial drugs even before their effects on pathogens. Clavulanic acid blocks the action of enzymes, restoring the sensitivity of bacteria to amoxicillin. In particular, it has a high activity for plasmid beta-lactamases, which are often associated with drug resistance, but less effective against type 1 chromosomal beta-lactamases.
The presence of clavulanic acid in the composition of Augmentin 1000 protects amoxicillin from the destructive action of beta-lactamases and expands its spectrum of antibacterial activity with the inclusion of microorganisms usually resistant to other penicillins and cephalosporins.
– hypersensitivity to beta-lactams, for example, kpenicillinam and cephalosporins
– jaundice or liver dysfunction, developed against a background of application of Augmentin 1000 or beta-lactam antibiotics
– Infectious mononucleosis
Interaction with other drugs
It is not recommended to use Augmentin 1000 simultaneously with probenicid. Probenicid reduces the tubular secretion of amoxicillin and, therefore, the simultaneous use of Augmentin 1000 and probenida can lead to an increase in blood levels of amoxicillin.
The simultaneous use of allopurinol and Augmentin can increase the risk of allergic reactions. Data on the simultaneous application of allopurinol and Augmentin are not currently available.
Augmentin affects the intestinal flora and leads to a decrease in reverse absorption, a decrease in the effectiveness of combined oral contraceptives.