Tretizen-20 – (active component – 20 mg isotretinoin) is an effective and modern means for treating acne, when traditional methods are powerless. Produced in the form of capsules.
The drug acts due to the active type of vitamin A, which has an increased synthesis in the human body. Isotretinoin is actively synthesized in the form of tretinoin and similar transformations of nuclear ligands that modify gene expression and protein synthesis (types of induction or inhibition), which depends on the degree of tissue damage.
Tretizen-20 reduces the activity and the sebaceous glands, which leads to a decrease in Propionibacterium acnes, which isotretinoin itself cannot provide. The drug has a complex antibacterial effect. The drug is an excellent anti-inflammatory agent with an antiseptic effect that reduces the external signs of seborrhea and slows down the temperature differentiation of keratinocytes. With regular application it accelerates the regeneration process of skin tissue cells.
The drug is used for various forms of acne or acne, including the treatment of pustular diseases, as well as bleeding, draining and prone to acne and acne scarring. The drug works when standard therapy is contraindicated. The drug is prescribed in the complex treatment of rosacea, severe forms of folliculitis caused by the pathogenic action of m / o, as well as purulent hydradenitis (with additional treatment). The drug is also effective in the treatment of horny tissue dysfunctions, the Tretizen-20 (isotretinoin) price is available for the treatment of the course
Contraindications to the drug:
Tretizen 20 from acne is contraindicated with high sensitivity to the ingredients of the drug, the period of pregnancy and lactation (the drug has an embryotoxic effect). In the presence of vitamin A hypervitaminosis, the use of a remedy is also prohibited. The rectal form of the drug is not recommended for use in rectal diseases. Various types of metabolic disorders (familial form of the disease, all forms of alcoholism, obesity, diabetes). Active ingredient Isotretinoin increases the concentration of triglycerides in the body, which leads to an increased risk of cardiovascular dysfunction. The drug is not used for liver disease, kidney failure, chronic pancreatic disease, diabetes mellitus or addiction to it.
Tretizen-20 from acne should be taken orally immediately before or after a meal. In the treatment of acne vulgaris, the daily dose of the drug is 0.5 mg per kg of body weight. The course of treatment – 1-2 doses per day for 2-4 weeks. Thereafter, the dose should be doubled and the treatment continued for another 10-20 weeks. The highest daily dosage is 2 mg kg. The dose can be adjusted according to the personal tolerability of the drug and the presence / absence of side effects. Usually, visible improvement can be achieved after the first month of regular use of the drug.
Clinical remission comes after 4-5 months of disease treatment. The effectiveness is considered to be a significant reduction in acne of 70% or more. In case of relapse of the disease, treatment is suspended for 7-8 weeks, after which the course should be resumed. When the disease worsens, the dosage of the drug should be halved for 2 weeks. In case of clinical remission, the dosage of the drug decreases. Rectally, the drug should be taken at 0.5-1 mg at bedtime for 8-12 weeks. The break between courses should be 1-2 weeks.