Description
FEATURES
Oxydrolone has unusually strong androgenic effects. It can provide a great gain in strength and mass in a very short time. Since it has a significant amount of water, the typical swollen look of the muscles. It is mainly used in the volume period, when it acts as a growth accelerator with a strong pump effect and helps maintain a high level of strength in training. In addition, it has a strong regenerative effect. Many athletes also use it to protect high-load joints.
Oxydrolone is derived from dihydrotestosterone (DHT). That is, oxymetholone is essentially a modified dihydrotestosterone. Other compounds from the anabolic steroid group are derived from DHT stanozolol, methenolone, drostanolone, oxandrolone and many more. Oxydrolone differs from DHT with the addition of a methyl group attached to carbon in position 17, and the 2-hydroxymethyl group is attached to the first carbon atom on the cycloalkane ring. These changes allow oxymetholone to remain active in muscle tissue, where dihydrotestosterone is normally disposed. The enzyme responsible for the breakdown of dihydrotestosterone in muscle tissue is called 3-hydroxysteroid dehydrogenase. With the aforementioned chemical modifications, the enzyme does not react with oxymetholone. This allows the compound to remain active in the muscle tissue and provide a very strong effect. Oxymetholone has anabolic strength in the value of 320 (more than 3 times the strength of testosterone, which has an anabolic power of 100 value). It has also been found to have lower androgenic strength (value 45) than testosterone (value 100). .
One of the unique and mysterious characteristics of oxymetholone is that, while it is a derivative of dihydrotestosterone, it has a very high level of estrogenic activity. Dihydrotestosterone derivatives should not be able to convert to estrogen by the aromatase enzyme, and thus do not cause estrogenic effects, but it is different with oxymetholone. Oxymetholone is also known to cause excessive water retention, bloating, gynecomastia, and other estrogenic effects in the body, although it does not convert to estrogen.It is believed that in some tissues it acts as an estrogen. It is necessary to note that all potential users know that although Oxymetholone is a derivative of dihydrotestosterone, they cannot expect the solid and quality gains that are typical of other DHT derivatives. The estrogenic effects of oxymetholone cannot be combined with aromatase inhibitors due to the fact that it is unable to convert into estrogen.
SIDE EFFECTS
Oxymetholone belongs to the group of anabolic androgenic steroids with the most harmful effects and many directly associate this substance with liver cancer. It can cause liver failure, which is initially manifested in high values, but after prolonged use of this substance it leads to liver damage. Among the estrogenic side effects there is the emergency of the gynecomat. The high retention of salt and water increases blood pressure. Oxymetholone has a significant impact on reducing testosterone production. Increase the number of red blood cells. Part of the active ingredient is converted into dihydrotestosterone (DHT); consequently acne and hair loss. Other side effects can be headache, nausea, stomach pain, vomiting, insomnia and diarrhea. When taking oxymetholone, a paradoxical situation often arises when a bodybuilder is gaining weight and strength, but does not feel particularly well. It strongly affects the conversion of carbohydrates into glycogen. In case of insufficient carbohydrate intake it can induce a state of hypoglycemia. Increased level of aggression is attributed to increased androgen levels and is still raised in simultaneous application of large doses of testosterone. It leads to changes in HDL (good) and LDL (bad) cholesterol values. Earn money from substance.
The first studies on hepatic oxymetholone toxicity in AIDS patients, showed a detrimental effect in the dose of 40 and 80 mg, but not in a dose of 20 mg per day. (Detection of steroid liver toxicity, however, is now generally problematic because it is an isolated sample of some of the oxymetholone on the group of elderly men (65-80 years), who received 50 or 100 mg of oxymetholone daily for 12 weeks. It was shown that in both groups Oxydrolone significantly reduced HDL cholesterol levels, but the burden on the liver (the measurement of the activity of the liver enzymes AST and ALT) surprisingly occurred only in the group treated with 100 mg / day, and again it was not dramatic.
DOSAGE
It is one of the few anabolic androgenic steroids, which abused dose is considerably lower than the so-called therapeutic dose, commonly used in the treatment process. The package insert generally indicates a therapeutic dosage of 1-5 mg per kg of body weight. The available information indicates that athletes due to the high toxicity of the substance to opt for the optimal dose to be 50-100 mg per day. Its half-life (biological half-life) is 8-9 hours. Obviously, only short term abuse of the substance needs to be considered (maximum 3-5 weeks) because the receptors that react to these substances only do so for a short time. However, as oxymetholone causes a significant reduction in the level of natural androgens, after discontinuation the vast majority of gains are lost. PCT quality is therefore a necessity.
Athletes take Oxymetholone mainly as a "starter" substance at the beginning of the injection cycle, the effect of which is slow (for example with testosterone, nandrolone, methenolonom, boldenone) .Separate use of oxymetholone makes no sense, because the results are hardly sustainable. Studies show that the substance remains in the urine for 50-60 days.
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