GW1516 (also known as Endurobol)) is not a steroid; is a selective agonist of peroxisome proliferator activating receptors (PPARs). It was originally developed for the treatment of obesity, diabetes mellitus, dyslipidemia, and cardiovascular disease.
GW1516 has a wide variety of effects in the body such as the energy processes of the cells, the production of insulin, the oxidation of fatty acids and also has a positive impact on muscle inflammation.
GW1516 activates the protein kinase activated by adenosine monophosphate (enzyme involved in energy processes in our body) and therefore stimulates the absorption of glucose in skeletal muscle tissue. In studies GW1516 has shown the ability to restore metabolic disorder in obese men with prediabetes syndrome, most likely through the stimulation of fatty acid oxidation.
In studies GW1516 showed protective and muscular effects and this appears to be related to a decrease in inflammation and muscle damage. GW1516 has been shown to elicit cardiovascular protection, possibly due to its actions in reducing insulin spikes and stabilizing cholesterol levels as found in research. It is evident that GW1516 not only reduces very low density lipoproteins (VLDL), but also increases high density lipoproteins (HDL), which is the result of an increased expression of the cholesterol transporter ABCA1, caused by GW1516 .
From the beginning GW-1516 has been accompanied by defamatory information. The World Anti-Doping Agency (WADA) puts it on the list of drugs that are dangerous to health, justifying this action with the declaration that the drug could presumably contribute to carcinogenesis. So, according to research from GlaxoSmithKline, the drug caused cancer in rats. In these studies, rats undergoing administration were administered at non-physiological dosages of 10 mg / kg body weight. Let's analyze an analogy with a human being: for a man of about 200 pounds (about 90 kg) this dose would be equal to 900 mg per day. These dosages defy any common sense, not to mention that they cannot be compared to a standard compound dose of 20 mg per day. 900 mg / day of GW1516 is comparable to the intake of 14625 mg of aspirin per day (while the single standard dose does not exceed 325 mg). Forget cancer, this aspirin dosage could literally kill you!
There are two main uses of GW1516 is sports. First, to increase endurance. The test results showed a 68% increase in endurance in rats while running on a treadmill while taking GW1516. A common dose of 10 mg / day will ensure a substantial improvement in endurance. When used in bodybuilding GW1516 can significantly reduce the rest time between sets.
The second reason for using GW1516 is fat burning. The drug has demonstrated the ability to burn fat, while being non-catabolic, it means it helps burn fat and maintain muscle.
In fact, GW1516 showed no significant side effects. There is no hormone suppression, no toxicity and no other common side effects. The only thing that should be noted is that GW1516 significantly activates the metabolism and contributes to the rapid consumption of glycogen during exercise, so do not exceed the recommended dosages; otherwise signs of hypoglycemia may occur (weakness, drowsiness, hunger, muscle cramps, in severe cases – loss of consciousness). If you feel any of these signs, immediately eat something sweet (containing fast carbohydrates).