Description
Azab 100 (Azithromycin) is a semi-synthetic antibiotic, the first of a subclass of azalides slightly different in structure from classical macrolides.
Obtained by modifying 14-member macrolides by including the nitrogen atom in the lactone ring between 9 and 10 carbon atoms, in which the ring is transformed into a 15-membered member. This restructuring leads to a significant increase in the acid resistance of the drug – up to 300 times compared to erythromycin.
Action of Azithromycin
Broad spectrum antibacterial azalide, bacteriostatic. Communicating with the 50S-ribosomal subunit, it inhibits peptidtranslokazu in the translation stage, inhibits protein synthesis, inhibits the growth and reproduction of bacteria, in high concentrations it has a bactericidal effect. It acts on extracellular and intracellular pathogens.
indications
Infections of the upper respiratory tract and upper respiratory tract caused by sensitive pathogens: pharyngitis, tonsillitis, laryngitis, sinusitis, otitis media; scarlet fever; lower respiratory tract infections: pulmonary bronchitis (including atypical, chronic exacerbation); skin and soft tissue infections: erysipelas, impetigo, secondarily infected dermatoses; Urinary tract infections caused by Chlamidia trachomatis: gonorrheal and negonoreyny urethritis, cervicitis; Lyme disease (early stage), peptic ulcer and 12 duodenal ulcer associated with Helicobacter pylori (in a combination therapy).
Azithromycin side effects
Hypersensitivity (including macrolide), hepatic and / or renal insufficiency.
From the digestive system: ingestion – diarrhea (5%), nausea (3%), abdominal pain (3%); 1% or less – flatulence, vomiting, melaena, cholestatic jaundice, elevated "hepatic" transaminase; Also, in children – constipation, decreased appetite, gastritis; candidiasis of the oral mucosa.
From the CCC: palpitations, chest pain (1% or less).
From the nervous system: dizziness, headache, drowsiness, sensorineural deafness, tinnitus; in children – headache (in the treatment of otitis media), hyperkinesis, anxiety, neurosis, sleep disturbances (1% or less).
From the urogenital system: vaginal candidiasis, nephritis (1% or less).
Allergic reactions: skin rash, hives, itching, angioneurotic edema; a / in the introduction – bronchospasm (1% or less).
Local reactions: at / in the introduction – pain and inflammation at the injection site.
Other: asthenia, photosensitivity; in children – conjunctivitis; change flavor (1% or less).
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